CurQD® is effective for:
- Crohn’s Disease
- Ulcerative colitis
- Crohn’s Colitis
- Proctitis
What is CurQD®?
CurQD® is a combination of two herbal materials mixed together, taken in personalized doses, to provide gut relief, reduce inflammation, and safely induce long-lasting remission. Our high quality clinical trials, performed at multiple centers across the world, discovered the best compounds to bring gut health to you, the patient:
- Cura: A form of curcumin derived directly from the turmeric root, Cura utilizes the anti-inflammatory and anti-oxidant properties of the turmeric plant to heal gut walls and restore their integrity to prevent symptoms in the first place.
- QD1: An extract of Indigo naturalis plants shown in clinical trials to resolve bleeding, reduce inflammation, and promote mucosal regeneration (Naganuma et al, Gastroenterology 2018; Ben-Horin et al, CCFA 2023).
After decades of research, CurQD® was born, and remains as a tailored protocol for individual patients depending on disease severity.
In our 2022 retrospective trial on active UC, we adjusted and tapered the dose of each compound based on patient progress, and this personalized approach significantly improved response and remission rates—even in difficult-to-treat cases.
- Natural products
- Scientifically-backed dosage
- Adjusts to you and your changing needs.
Whether you’re suffering symptoms or seeking a safe, natural remedy to help manage your condition, we have a protocol for you.
Putting the Patient First with Personalized Care.
IBD is an ever-changing disease. CurQD® Protocols use clinically-tested evidence to personalize protocols to your condition and needs in the moment, to promote gut health for a lifetime.
Each 6-week protocol includes natural compounds at specific ratios found to improve patient clinical biomarkers and symptoms and increase remission outcomes.
These protocols have been refined through years of research, real-world implementation and international clinical trials to ensure precision, with tapering and adjustments from induction to remission.
For severe conditions, we use higher doses of QD1 (fast-acting, potent). As symptoms improve, we taper down QD1 and increase Cura (restorative, preventive) to help sustain long-term remission and reduce potential side effects caused by the powerful Qing Dai.
The Evidence
In a retrospective study on the CurQD® Protocol presented at the United European Gastroenterology conference (Vienna), researchers analyzed difficult-to-treat patients referred from five top Israeli medical centers.
- All had severe disease activity.
- 46% were non-responsive to biologics.
- 41.5% to corticosteroids.
- 31.1% to biologics/small molecule therapy.
After 8–12 weeks on CurQD®, 78% achieved clinical response & remission.
Learn more about the science behind CurQD® on our Science Page, where we break down the latest trials and formulations.
Approved by Leading Gastroenterologists
“My experience with this combination is very good. We’ve had some patients who were able to avoid advancing them to biologics, and others we could give this combination to instead of steroids. ”
~ Dr. Dror Shoval MD, Senior Pediatric Gastroenterologist
“I admit I was skeptical about these treatments. But with time I realized patients were reporting a significant benefit and I was surprised to see that they were improving – not just subjectively but objectively.”
~ Henit Yanai MD, Senior Gastroenterologist
Resources
Downloadable PDFs for patients and doctors:
FAQ
What is CurQD®?
CurQD® contains two herbal extracts in differing ratios which we tailor to different states of disease severity:
Cura: A gut-directed form of curcumin shown in placebo-controlled trials to exert a positive impact on clinical and endoscopic remission (Lang et al, CGH 2015). Cura has been found to reduce inflammatory cytokines, restore barrier function and positively alter the composition of the gut microbiome.
QD: An extract of Indigo plants found in clinical trials to relieve bleeding, inhibit inflammation and promote mucosal regeneration (Naganuma et al, Gastroenterology 2018, Ben-Horin et al, CCFA 2023).
Due to the rapid effects of QD and the long-term maintenance profile of Cura, as seen in clinical studies, we’ve combined the two with specific ratios ensuring the speed, efficacy, and safety for each phase of treatment: remission induction, gut repair, and remission maintenance.
Can I take CurQD® with my current medication?
All 5-ASA medications, steroids and biologics can be taken with CurQD®. CurQD® has even been proven to enhance the efficacy of these medications to improve gut healing and support recovery. For more specific questions, please reach out to info@curqd.com.
How long will it take for me to reach remission?
Every patient is different.The combination of both anti-inflammatory ingredients, Cura (95% pure gut-directed curcumin) and QD (Qing Dai), work together to combat IBD flare-ups and relieve severe symptoms. It is a short-term treatment meant to induce remission.
Once symptoms and inflammatory markers come under control, you will continue to taper down gradually until you reach the Blue+ Protocol. This protocol bridges the gap between remission induction treatment (Red, Orange, Yellow, Green Protocols) and remission maintenance treatment (Blue Protocol – Cura only).
In our experience, proper adherence to the CurQD® Protocol combined with small lifestyle adjustments leads to a decrease in symptoms, if not remission itself.
What protocol should I take?
Every new patient begins with the Green Protocol, which assists patients in acclimating to the CurQD® combination. Afterwards, they will take a personalized protocol based on their disease severity or presentation. For more information, please email info@curqd.com.
How does it relieve inflammation?
Our natural formulas contain molecules that activate a specific immunological pathway initiated by the aryl hydrocarbon receptor (AhR). When activated, this pathway accelerates the reconstitution of intestinal integrity in IBD patients, leading to complete mucosal healing.
The AhR pathway is now a new focus of emerging novel treatments for IBD. CurQD® is the first formulation shown in clinical trials to induce remission through the activation of this pathway.
Why 6 weeks?
Our experience and clinical trials show that your condition will change and improve after each 6-week protocol. Therefore you’ll require a different protocol to smoothly transfer you toward remission. Each protocol slightly tapers down the fast-acting Qing Dai (QD) and increases the ratio of the preventive gut-directed curcumin (Cura).
In our recent clinical trials, we found this adjustment vastly improved rates of remission. In fact, the results were unprecedented, showing efficacy even in patients who did not respond to biologics.
What are the daily doses?
Four capsules daily: two in the morning with food, two in the evening with food.
Can I take CurQD® long-term?
CurQD® Protocols should be used to induce remission.
CurQD® products can be used for up to 6 months at a time. Ideally, your dose will gradually decrease within this period.The gradual reduction in dose supports a smooth transition into remission. Maintenance protocols Blue+ and Blue can be used beyond this 6 month period.
The Blue Protocol, containing only Cura, is intended for extensive, long-term use and should be used during the remission maintenance phase.
Is CurQD® safe for children?
The Blue and Blue+ CurQD® Protocols are approved for use in children from ages 5 and above. The full CurQD® Protocol is approved for use in children ages 8 and above.Dosing is dependent on age and weight.Please note, this is given only as general information and we always recommend consulting with your physician on such treatment decisions.
Will CurQD® help stop the bleeding?
Bleeding is usually one of the first symptoms to resolve, typically within 2–6 weeks. If bleeding does not resolve, or returns after this period, please refer to info@curqd.com for more information.
What are the potential side effects of CurQD®?
Headaches – commonly experienced in the first 72 hours of treatment
Mild transient elevation of liver enzymes – blood tests are recommended 3-6 weeks after starting CurQD® (assessing ALT and AST)
Shortness of breath
Any unexplained symptom
Unfamiliar abdominal pain and/or severe diarrhea may be a sign of a rare delayed allergic reaction that may progress to intussusception/ischemic colitis. Please stop treatment immediately and contact info@curqd.com for next steps.
Qing Dai has on rare occasions been associated with pulmonary arterial hypertension (PAH) which dissipated upon discontinued use. Zero cases have been reported with CurQD®.
What if I’m already in remission?
Once you have achieved remission, contact info@curqd.com to begin maintenance phase treatment. Make sure to check in with your gastroenterologist, and use the Blue protocol as instructed to further strengthen gut walls, maintain gut motility, and prevent future flare-ups.
For more information, email info@curqd.com.
Does it help with Microscopic colitis?
None of our clinical trials have tested the efficacy of CurQD® on microscopic colitis, however our experiential evidence from our Clinic demonstrates microscopic colitis treatment success with CurQD®.
For more information, please reach out to info@curqd.com.
Why can’t I just use normal curcumin?
Most commercially-available curcumin products have enhanced absorption (or high bioavailability) using different additives such as black pepper or a phospholipid complex. These are generic curcumin products developed to treat general inflammation mostly outside the GI tract, such as arthritis or hepatitis. This mechanism is not suitable for IBD as the active compounds lose concentration and potency before reaching the distal intestinal tract.
Cura is ‘gut-directed’, meaning it is specifically designed to reach high concentration in the gut so it can make direct contact with the intestinal lining of the digestive tract. It is the only curcumin product developed specifically for the treatment of IBD and was tested with great success in our clinical trials for IBD, as seen in a meta-analysis showing significantly higher efficacy rates for Cura compared to other forms of curcumin for UC.
Is curcumin the same as turmeric?
No. Curcumin is the active compound; turmeric only contains ~2%. We use 95% concentration.
Will any Qing Dai formula work?
As far as we are aware, Evinature’s QD is the only Qing Dai on the market to be proven to contain indigo and indirubin through LCMS-testing; without these crucial ingredients, commercially-available Qing Dai may not offer any benefit to those with chronic intestinal inflammation.
Complementing each other and working on different biological mechanisms, the two compounds in CurQD® at our specific ratios help lower tissue inflammation and promote the healing and regeneration of the mucosal layer of the gut. In our clinical research and experience they have been found very effective in helping those with active flares go back into remission.
If you are using another form of Qing Dai, do not combine treatments.